The Justice League faces a powerful new threat — the Fatal Five! Superman, Batman and Wonder Woman seek answers as the time-traveling trio of Mano, Persuader and Tharok terrorize Metropolis in search of budding Green Lantern, Jessica Cruz. With her unwilling help, they aim to free remaining Fatal Five members Emerald Empress and Validus to carry out their sinister plan. But the Justice League has also discovered an ally from another time in the peculiar Star Boy — brimming with volatile power, could he be the key to thwarting the Fatal Five? An epic battle against ultimate evil awaits!

In an alternative Victorian Age Gotham City, Batman begins his war on crime while he investigates a new series of murders by Jack the Ripper.

Batman and Nightwing are forced to team with the Joker's sometimes-girlfriend Harley Quinn to stop a global threat brought about by Poison Ivy and Jason Woodrue, the Floronic Man.

As Batman hunts for the escaped Joker, the Clown Prince of Crime attacks the Gordon family to prove a diabolical point mirroring his own fall into madness.

A heroic version of Lex Luthor from an alternate universe appears to recruit the Justice League to help save his Earth from the Crime Syndicate, an evil version of the League. What ensues is the ultimate battle of good versus evil in a war that threatens both planets and, through a devious plan launched by Batman's counterpart Owlman, puts the balance of all existence in peril.