A full moon rises in Beacon Hills, and with it a terrifying evil has emerged. The wolves are howling once again, calling for the return of Banshees, Werecoyotes, Hellhounds, Kitsunes, and every other shapeshifter in the night. But only a Werewolf like Scott McCall, no longer a teenager yet still an Alpha, can gather both new allies and reunite trusted friends to fight back against what could be the most powerful and deadliest enemy they’ve ever faced.

CDC researcher Abby Arcane investigates what seems to be a deadly swamp-born virus in a small town in Louisiana but she soon discovers that the swamp holds mystical and terrifying secrets. When unexplainable and chilling horrors emerge from the murky marsh, no one is safe.

Cal Weaver is living the American dream. He has a good job, a beautiful house, great children and a beautiful wife, named Emily. Cal's seemingly perfect life unravels, however, when he learns that Emily has been unfaithful and wants a divorce. Over 40 and suddenly single, Cal is adrift in the fickle world of dating. Enter, Jacob Palmer, a self-styled player who takes Cal under his wing and teaches him how to be a hit with the ladies.

Strange lights descend on the city of Los Angeles, drawing people outside like moths to a flame where an extraterrestrial force threatens to swallow the entire human population off the face of the Earth.