The series focuses on an eccentric motley crew that is the Smith family and their three housemates: Father, husband, and breadwinner Stan Smith; his better half housewife, Francine Smith; their college-aged daughter, Hayley Smith; and their high-school-aged son, Steve Smith. Outside of the Smith family, there are three additional main characters, including Hayley's boyfriend turned husband, Jeff Fischer; the family's man-in-a-goldfish-body pet, Klaus; and most notably the family's zany alien, Roger, who is "full of masquerades, brazenness, and shocking antics."

Six months after the events of Monsters, Inc., the city of Monstropolis is now fueled with the sound of laughter. Tylor Tuskmon, a mechanic on the Facilities Team, dreams of working alongside his idols Mike Wazowski and James P. 'Sulley' Sullivan.

Siblings Dean and Sam crisscross the country, investigating paranormal activity and picking fights with demons, ghosts and monsters.

When world-famous air racer Dusty learns that his engine is damaged and he may never race again, he must shift gears and is launched into the world of aerial firefighting. Dusty joins forces with veteran fire and rescue helicopter Blade Ranger and his team, a bunch of all-terrain vehicles known as The Smokejumpers. Together, the fearless team battles a massive wildfire, and Dusty learns what it takes to become a true hero.