A road rage incident between two strangers — a failing contractor and an unfulfilled entrepreneur — sparks a feud that brings out their darkest impulses.

Alexa is battling cancer. But with her best friend, Katie, by her side, she's also starting high school -- and ready for whatever comes next.

20 years after the dimwits set out on their first adventure, they head out in search of one of their long lost children in the hope of gaining a new kidney.