More than two decades after the events of Terminator 2: Judgment Day, Sarah Connor sets out to protect a young woman named Dani Ramos and her friends, as a liquid metal Terminator, sent from the future, attempts to terminate them.

A group of troubled passengers wake up on a damaged spaceship abandoned in deep space, each having left behind a dark past in search of a fresh start on a newly colonized planet. As their terrifying situation spirals into paranoia, they come to realize that the greatest threat to their dream of starting over – and indeed their lives – is something far darker than the pasts they were so desperate to escape.

Picking up immediately after the events in Resident Evil: Retribution, Alice (Milla Jovovich) is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began - The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.