Former CIA spy Bob Ho takes on his toughest assignment to date: looking after his girlfriend's three kids, who haven't exactly warmed to their mom's beau. And when one of the youngsters accidentally downloads a top-secret formula, Bob's longtime nemesis, a Russian terrorist, pays a visit to the family.

To everyone's surprise, including his own, Po, an overweight, clumsy panda, is chosen as protector of the Valley of Peace. His suitability will soon be tested as the valley's arch-enemy is on his way.

After a secret agent is hospitalized, his chauffeur reluctantly takes his place as a super-spy — thanks to the help of a tricked-out dinner jacket.