Go Da Kyung is an eager rookie investigator who gets paired with the famous forensic doctor, Yoon Ji Hoon. They initially clash due to their different styles of investigation as well as their opposing personalities, but later develop a complex relationship as the two strive to uncover the truth through science.

Do Il-Chool (Park Jung-Min) has a talent for playing poker and he is the son of Jjakgwi. His father was a gambler and had one ear cut off after he was caught cheating. Il-Chool meets mysterious gambler Aekku (Ryoo Seung-Bum) and gets involved in the master gambling world.