An emotional thrill ride through the day-to-day chaos of the city's most explosive hospital and the courageous team of doctors who hold it together. They will tackle unique new cases inspired by topical events, forging fiery relationships in the pulse-pounding pandemonium of the emergency room.

A newly-released prison gangster is forced by the leaders of his gang to orchestrate a major crime with a brutal rival gang on the streets of Southern California.

A runaway train, transporting deadly, toxic chemicals, is barreling down on Stanton, Pennsylvania, and proves to be unstoppable until a veteran engineer and young conductor risk their lives to try and stop it with a switch engine.