A home-searching romance story about a man who buys houses and a woman who lives in one. It follows the diverse stories of the editors of a home magazine.

Woo Yeon met her first love, Lee Soo, in high school. Soo always helped Woo Yeon whenever she was in trouble and was sweet to her. One day, before Woo Yeon had a chance to ask him out, he told her that he's leaving to study in the US.

The essence of love is fading and is evermore harder to do. In this day and age, will there be love that is woeful and forlorn just for the sake of love itself? Love in Sadness is a love story that encapsulates the mythical-like fate of love that is so coveted that it ignores all bounds. In it, love outweighs what the world thinks, ignores the pain and anguish with it, and pursues its destiny. In the drama, Ma Ri is a beautiful girl, married into wealth with a seemingly perfect life. Ironically, her husband, In Wook, who looks like a more than ideal husband, is an obsessive lunatic who is also violently abusive. When he pushes her too far, she reaches out for help from Jung Won, an honest, smart, handsome plastic surgeon. And when he agrees to help her escape from her husband's hands, they fall in love. But In Wook, who is consumed by his obsession for her, isn't going to let her get away from his grasp. Watch as these two characters struggle to stay on their arduous road to love.