After his capture for attempted assassination of the Raikage, leader of Kumogakure, as well as killing J?nin from Kirigakure and Iwagakure, Naruto is imprisoned in H?zukijou: A criminal containment facility known as the Blood Prison. Mui, the castle master, uses the ultimate imprisonment technique to steal power from the prisoners, which is when Naruto notices his life has been targeted. Thus begins the battle to uncover the truth behind the mysterious murders and prove Naruto's innocence.

A mysterious group of ninjas makes a surprise attack on the Konohagakure, which takes great damage. The nightmare of another Shinobi World War could become a reality. Sasuke, who was still a missing nin from Konoha trying to kill his brother, Itachi, appears for the second time in front of Naruto at an unknown location to prevent it from happening.

To prevent a ninja from reviving a powerful demon that could destroy the world, Naruto teams up with a young priestess, despite her vision of his death.

Ninjas with bloodline limits begin disappearing in all the countries and blame points toward the fire nation. By Tsunade's order, Kakashi is sacrificed to prevent an all out war. After inheriting charms left by Kakashi, Naruto fights through friends and foes to prevent his death while changing the minds of those who've inherited the will of fire.

Guided by the spirit demon within him, orphaned Naruto learns to harness his powers as a ninja in this anime adventure series.