As part of a racist government policy now known as the Sixties Scoop, Bezhig Little Bird is removed from her home in Long Pine Reserve in Saskatchewan and adopted into a Montréal Jewish family at the age of five, becoming Esther Rosenblum. Now in her 20s, Bezhig longs for the family she lost and is willing to sacrifice everything to find them.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

After losing his job, a stay-at-home dad jumps at the chance to start a day care center, inviting new kids and all kinds of shenanigans into his home.