A large meteor crashes into a quiet town, and pet dogs become mysteriously aggressive. attacking and killing the residents. Teenager Roslyn (Mays) and her old but faithful dog Shep are out camping when the attacks hit. Now separated by the chaos in town and blocked roads, Roslyn and the other members of her family must find each other by fighting back against the blood-thirsty hounds before the dogs take over the whole town and escape becomes impossible.

Dr. Martin Blake, who has spent his life looking for respect, meets an 18-year-old patient named Diane, suffering from a kidney infection, and gets a much-needed boost of self-esteem. However, when her health starts improving, Martin fears losing her, so he begins tampering with her treatment, keeping Diane sick and in the hospital right next to him.