After a scientific experiment leads to the creation of a clone of Mewtwo, he sets out to destroy the world. Ash and his friends then decide to thwart Mewtwo's evil plans.

In a country called "Diamond Domain" lies the powerful Heart Diamond, which has served as the kingdom's source of energy and maintained the Ore Country for centuries. Many Carbink live in Diamond Domain, including their princess - the Jewel Pokémon, Diancie, who created the Heart Diamond. Diancie no longer has the power to control the Heart Diamond and her country is falling into chaos as a result. One day, Diancie meets with Ash and his friends and asks them to go on a journey to find the Life Pokémon, Xerneas, in order to restore the Heart Diamond. Standing in their way is the Pokémon of Destruction, Yveltal, who once stole all of the life in the Kalos Region. During their journey they are attacked by Team Rocket, as well as the jewel thieves Marilyn Flame and Ninja Riot. They are aided by Millis Steel and her father Argus, travelers who also encounter the Cocoon of Destruction.

Yu-Gi-Oh! Zexal is a Japanese manga and anime series and the third main spin-off series of the Yu-Gi-Oh! franchise. The manga began serialization in Shueisha's V-Jump magazine from December 2010 and is licensed in North America by Viz Media. The anime series, produced by Nihon Ad Systems and Studio Gallop, aired on TV Tokyo between April 2011 and September 2012, following the previous anime series, Yu-Gi-Oh! 5D's, with an English-language version airing in North America between October 2011 and August 2013. A second series, Yu-Gi-Oh! Zexal II, began airing in Japan on October 7, 2012 and in North America from August 18, 2013. The series aired on The CW's Saturday morning cartoon block, Toonzai, and continues to air on its successor, Vortexx, later airing on Nicktoons from April 2013. It now airs every Sunday at 11:30,on Nicktoons.